The Italian Team discovered two new cannabinoids, one is 33 times more potent than THC

the ROME - Have been isolated and identified for the first time in the world, two new phytocannabinoid from cannabis sativa. This is thanks to a research team led by Giuseppe Cannazza of the Department of Life Sciences of the University of Modena and Reggio Emilia (Unimore) in collaboration with the CNR-Nanotec of Lecce, the section of Pharmacology of the University of the Campania region and the Department of Chemistry at the University La Sapienza of Rome.

The two cannabinoids just discovered, thanks to new techniques of mass spectrometry, are the THCP and the CBDP extracted from cannabis as a medicine is FM2 produced by the chemical-pharmaceutical Institute Florence military. The in vivo study showed that the compound THCP has an interaction with the receptor for cannabinoids, 33 times higher compared to THC and thanks to this increased activity psychotropic in vivo tests, conducted on mice in the laboratory, the THCP is active at lower doses. The mechanisms of action, however, the CBDP are still little known as those of the CBD.

The discovery, published in the journal Scientific Reports, opens new avenues towards the understanding of the effectiveness in the therapeutic field of cannabis, such as the treatment of pain, epilepsy, or the treatment of anxiety and depression. "The knowledge of the chemical composition of cannabis - explain Cannazza - is the basis for understanding the therapeutic effects of the different varieties that are already used as drugs for diseases, such as forms of epilepsy severe in children or in the treatment of neuropathic pain of multiple sclerosis and cancer."

"The importance of this discovery, they added, researchers Cinzia Citti and Easter Linciano of the Ru - resides in the fact that so far no one has ever tried the THCP in the different varieties of cannabis. The next step will be to search for the concentration of these cannabinoids in the other varieties in order to find out the reason for which some of the varieties with a low THC level properties of psychotropic extremely high. And one answer might be the THCP. With regard to the CBD, however, we do not know absolutely that pharmacological activity may have".

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