Only a month ago, at the end of the University of Zurich, reported Researchers in the journal "Nature" of a new class of synthetic antibiotics with a unique point of attack. Now an international Team with the participation of the University of Basel to submit: describe in "Nature" – a new, natural ingredient called Darobactin that uses the same point of attack.
Darobactin is produced by certain bacteria, to competition by other bacteria. Found it, the Team, under the direction of the North Aster University in Boston in bacteria of the genus Photorhabdus, which are found in certain thread worms.
The newly discovered antibiotic is effective against a part of the outer shell of so-called gram-negative bacteria. These include some of the germs, which are classified by the world health organization as particularly dangerous.
promising point of attack
The point of attack of Darobactin is a membrane protein called BamA. This is for the construction of the outer envelope of gram-negative bacteria is important. Without BamA, the bacteria are not able to build the outer shell. You die. This point of attack had also described the researchers at the University of Zurich a month ago for a new synthetic antibiotic class called OMPTA.
"That we have found in the nature of a substance, which attacks the same unusual goal, confirmed clearly that BamA is a suitable point of attack for antibiotics," said Sebastian Hiller from the Biozentrum of the University of Basel according to a communication to the now published study. Hiller contributed in the framework of the National research programme "antimicrobial resistance" to clarify the mode of action of Darobactin.
Hiller believed that the new antibiotics against BamA not so fast, resistance can form. The BamA Protein is change for the bacteria to be resistant to attack by active agents at this point. In addition, it seats in the outer membrane of the bacteria, so that they could protect it, it is hard for the defense mechanisms from attack.
were able to Effectively prove against dangerous germs
Researchers at the Northeastern University in Boston in Tests with mice that Darobactin against infections with various antibiotic resistant germs, which are considered to be particularly dangerous. Including, for example, Klebsiella pneumonia, a gram-negative bacterium, pneumonia and other hospital-acquired infections can cause. Of these pathogens, multiple strains are known, which have become resistant to many antibiotics.
According to the WHO, especially gram-negative bacteria are a risk of the antibiotics against Carbapenem - and Cephalosporin-resistant. These pathogens can skin life - threatening infections such as pneumonia or brain inflammation, Wundinfekte and blood poisoning is the cause.
The last new antibiotic class, which came against these bacteria on the market, dates from the 1960s. New antibiotics are urgently needed, especially since in the meantime also resistance to the last Reserve-increase antibiotic Colistin. (step/sda)
Created: 20.11.2019, 22:35 Uhr