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Leukemia, the first child to the world will be healed with immunotherapy protected
IN recent years, the therapy is CAR-T has literally revolutionized the treatment of blood cancer that are not responding to chemotherapy: the T lymphocytes of the patient are picked up, reprogrammed to recognize the neoplastic cells and then reinfusi. The desired inflammatory reaction, however, can get out of control and compromise, about one fourth of the cases, the vital functions of the patient profile similar to leukemia treated with immunotherapy. Is the so-called syndrome release of cytokines, mediators of inflammation and sepsis, which in severe cases may lead the patient to death. To date, the syndrome has been treated with medications that do not always manage to control the inflammatory state, in addition to suppressing the immune system.

In an attempt to limit this side effect, without affecting the effectiveness of the gene therapy , in the past few months, doctors of the intensive care pediatric Red Zone and those of the pediatric Oncology department of the Bambino Gesù ' in Rome have successfully tested a new approach: cleanse, rapidly, and selectively, the blood. In the study published in the journal Critical Care Explorations, dr. Gabriella Bottari and colleagues reported the first case of a fourteen-year-old suffering from a severe form of acute lymphoblastic leukemia – the most common form in childhood, that every year in Italy, has a population of approximately 400 new cases – treated with CAR-T in combination with hemoperfusion, extracorporeal, after the onset of a severe form of the syndrome by release of citochinico. The little patient, who was admitted in the intensive care unit, pediatric had, in fact, developed a severe respiratory failure on the basis of the inflammatory distance to a week by the infusion of CAR-T and has been saved, and discharged after 15 days from the intensive care unit the pediatric.
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