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Deciphered the 'chatter' of cancer cells
the MILAN - Have cracked the 'chatter' of cancer cells: the exchange of messenger molecules that promote their uncontrolled growth, which was intercepted by examining individually the millions of cells that make up tumors in miniature (organoidi) grown in the laboratory from the cells of patients. The result has been obtained thanks to a new technique of analysis published by researchers at University College London in the journal Nature Methods. In the future will help to understand how cancer cells escape the controls of the immune system and how they become resistant to the therapies, in order to develop treatments more effective and customized.
"The organoidi are already revolutionizing cancer research, enabling us to test new drugs and understand if they are effective", explains the coordinator of the study Chris Tape . "Crucially, this new technique helps us to understand why a treatment works or not, revealing with unprecedented detail how the cells talk to each of them." This is possible thanks to a revised version of the flow cytometry mass: the technique pevede that the individual cells of the hero to be sprayed and then capture their signal molecules with specific antibodies, linked to heavy metals for ease of separation by applying a magnetic field.

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