The silent epidemic In Italy, the sick of dementia are more than 1 million, most of which are suffering from Alzheimer's, the disease that today affects about 5% of people over 65 years of age. “The who estimates that currently are 50 million patients suffering from various forms of dementia,” explains Sandro Sorbi , honorary president of Airalzh, University of Florence. “But the median survival is 4 years old, this means that 50% of the 50 million patients will die in the next 4 years and in fact the data could be higher given that the majority of people is sick in the developing countries where the mortality rate is higher. Are huge numbers comparable to other epidemics. I think, for example, the Spanish flu between 1918 and 1920 did between 50 and 70 million deaths, but then it's over while the dementias and the numbers are growing since life expectancy increases”. Little research and few funds Some of the data 2019 referred to the United States, the nation that most funds research on Alzheimer's disease reported that the funds for the Alzheimer's and related diseases amounts to about us $ 2 billion, compared to the 6 billion dollars spent for research on cancer. In the world there are only 50-60 clinical trials of experimental Alzheimer's disease each year, compared to 500 for all cardiovascular diseases and 2,500 for the cancer. In Italy the situation is even worse. Istat data show that investment in research does not reach 1.4% of Gdp. “We are particularly proud of the path done in these few years, – says - Sorbs - . Before the birth of the association, in 2014, Italy was the only western Country that is not collecting funds for research on Alzheimer's disease, and those who wanted to make a donation to cure this disease it was addressed to associations of other Countries”. "Incentives for research" on the basis of these data on the shortage of funds for research, the minister of Health, Roberto Hope , spoke, emphasizing how, with the new Budget Law - you are reversing the route: “Fifteen years of definanziamento were put to the test the seal of the National Health Service. Now we need to invert radically the season of the cuts and restart, and this Law of Balance indicates a contrast with the allocation of two billion on current spending”. But the minister reiterated that the resources are not enough: the need for the reforms by acting on the programming model of the expenditure on strengthening of community-based care to cope with chronic diseases that are exploding as, for example, Alzheimer's disease, and then by making better use of the potential of digital health. “Initiatives such as this in which the volunteer is a network with a central co-operative like the co-op, " he added, Hope - go in the same direction, and we should multiply them out. For our part, we put all the efforts to keep high the attention on Alzheimer's disease by encouraging research”. For the diagnosis, prevention, and new therapies the Three projects presented today among those that have produced interesting results in the field of early diagnosis, identification of new therapeutic targets, lifestyle and prevention. To Giorgio Fumagalli , a researcher at the Policlinico of Milan, is a project of the study of the sulci of the brain to improve the diagnosis between the different forms of dementia. On the front of prevention, Manuela Leri , a researcher at the University? of Studies of Florence, has studied the effects of polyphenols present in extra virgin olive oil on some of the alterations that characterize the pathology of Alzheimer's disease, confirming a direct effect of anti-inflammatory effect of the polyphenols on the cells and their capacity? to reduce the formation of amyloid plaques. the Silvia Pelucchi, a researcher at the University? degli Studi di Milano, instead, he worked on the identification of new therapeutic targets, and discovering a protein (CAP2) responsible for the structural modification of our neurons during the processes of learning and memory, which are altered in Alzheimer's disease. This study allows us to identify a target pharmacological innovative that it can intervene in the stages more? early in the disease characterized by a dysfunction of the contacts between the nerve cells.
300 thousand euro to finance research, in 2020, Therapies, early diagnosis, digital medicine, biomarkers: these are the themes on which Airalzh promises to continue to concentrate in the future to their attention. “For 2020 - raises Alessandra Mocali , president Airalzh, of the University? degli Studi di Firenze - will be? launched an open call independent for which we have allocated a budget of 300 thousand euros to finance projects of excellence - can be financed up to a maximum of 50 thousand euro – to continue the research on Alzheimer's disease research centers, public or private, located in Italy”. The announcement is addressed more in young applicants, and intends to give a contribution to the development of projects related to “life-Styles, and Alzheimer's disease” and “early Stages of the disease: identification of diagnostic markers, potential targets and pharmacological approaches new technology”. The campaign ‘Non ti scordar di te’ Coop has announced the will? to continue the collaboration with additional 7 research grants for young researchers. The total value the total paid by Coop for the research reaches around 2 million euro. To sustain the research, since 2016, in at 1,170 points of sale Coop? activated a campaign of awareness raising and information identifying the span of four years - as many as 47 products on which to place the slogan “Non ti scordar di te”, and to direct consciously the choices of the members and consumers. From olive oil to tomatoes, from pasta to parmigiano-up to the plan of erica that of the countryside? the product symbol:? the path was shared not only with members but also with suppliers who have participated in the project”.
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